HowTo: Prevent System Center Configuration Manager 2012 R2 (SCCM) distribution packages from being stored on selected drives
Prevent SCCM 2012 R2 distribution packages from being stored on selected drives
To prevent the distribution points content directory from being created and using the first drive install in the server i.e. C:\ drive, create a blank file named:
and copy it to the drives you do not want to be used for SCCM storage.